Effects of microinjection of OFQ into PAG on spinal dorsal horn WDR neurons in rats.
نویسندگان
چکیده
The aim of the present study was to examine the effect of microinjection of orphanin FQ (OFQ) into periaqueductal gray (PAG) on sensory processing in the wide dynamic range (WDR) neurons of the spinal dorsal horn and to explore the effect of OFQ on a descending system of pain modulation. The results show that microinjection of OFQ into ipsilateral PAG significantly facilitated C-fibre evoked response and post-discharge of spinal dorsal horn WDR neurons. This is consistent with our previous results obtained in behavioral studies. It suggests that the supraspinal effect of OFQ on pain may partly be mediated by PAG neurons.
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ورودعنوان ژورنال:
- Brain research
دوره 888 1 شماره
صفحات -
تاریخ انتشار 2001